Whole-Body Vibration Partially Reverses Aging-Induced Increases in Visceral Adiposity and Hepatic Lipid Storage in Mice


At old age, humans generally have declining muscle mass and increased fat deposition, which can
increase the risk of developing cardiometabolic diseases. While regular physical activity postpones
these age-related derangements, this is not always possible in the elderly because of disabilities or risk
of injury. Whole-body vibration (WBV) training may be considered as an alternative to physical
activity particularly in the frail population. To explore this possibility, we characterized whole-body
and organ-specific metabolic processes in 6-month and 25-month old mice, over a period of 14 weeks
of WBV versus sham training. WBV training tended to increase blood glucose turnover rates and
stimulated hepatic glycogen utilization during fasting irrespective of age. WBV was effective in
reducing white fat mass and hepatic triglyceride content only in old but not in young mice and these
reductions were related to upregulation of hepatic mitochondrial uncoupling of metabolism (assessed
by high-resolution respirometry) and increased expression of uncoupling protein 2. Because these
changes occurred independent of changes in food intake and whole-body metabolic rate (assessed by

indirect calorimetry), the liver-specific effects of WBV may be a primary mechanism to improve
metabolic health during aging, rather than that it is a consequence of alterations in energy balance.

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About the Author : Dr. Bill Deagle MD