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DR BILL'S PRODUCTS: NUTRIMEDS
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BRAIN MAG Berry Flavored Powder Container $44.95
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Common Uses:
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•• Supports Healthy Brain Magnesium Levels*
•• Supports Healthy Synapse Number and Function*
•• Supports Cognitive Health*
•• Supports Stress Management, Sleep Quality, and a Healthy Mood*
•• Helps Ensure an Optimal Magnesium Intake for Overall Health*
Clinical Applications
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
Brain Mag features the same Albion forms of magnesium found in Magnesium Chelate plus Magtein™
(magnesium L-threonate), the only form of magnesium proven in animal studies to cross the blood-brain
barrier. Boosting the brain’s magnesium level is vital to healthy cognition, which includes long- and shortterm
memory, learning, stress management, and sleep.*

Brain Mag – Optimizes Magnesium Delivery to Body and Brain
 
Dietary intakes of magnesium are consistentlymagnesium levels are not optimal, synapse function deteriorates. By
delivering magnesium into synapses, Magtein helps brain cells stay healthy, without being overactivated; consequently, brain cells respond to signals with clarity and robustness.*
Magtein Raises Brain Magnesium Levels
Studies show that Magtein crosses the blood-brain barrier and raises the brain’s magnesium levels, which result in increased magnesium deposits in neural synapses, increased neural synaptic density, and improved brain function.[2-4] One animal study showed that when the bioavailability of several magnesium compounds was compared to controls, only Magtein significantly
enhanced magnesium bioavailability and produced a significant increase (7% to 15%) in rat cerebrospinal fluid.[2] These small but significant increases in brain magnesium levels produced profound effects on neurological function.*
Magtein Supports Healthy Synaptic Number and Function
Maintaining extracellular magnesium in the brain helps preserve synaptic density and keeps the synapses working properly. [2,5] By increasing magnesium concentration in the extracellular fluid, researchers observed permanent enhancement of synaptic plasticity in networks of cultured hippocampal neurons.[5] Delving deeper into the mechanisms involved, later animal research showed that magnesium increased receptor signaling; specifically, the signaling of the NR2B-containing N-methyl-D-aspartate (NMDA) receptor. NMDA receptors are rich in the hippocampus and play a pivotal role in memory processes. Data from these studies suggest that increasing brain magnesium with Magtein “enhances both short-term synaptic facilitation and long-term potentiation and thereby supports synaptic plasticity and learning and memory functions
in rats.”*[2,3,6]
 
Magtein Supports Cognitive Health
 
The benefits of Magtein were observed in several pre-clinical animal studies that used assessments, such as the NORT
(novel object recognition test), T-maze, Morris water maze, conditioned fear memory, and conditioned taste aversion.
In these studies, researchers demonstrated that when brain magnesium levels were increased, significant benefits were detected in multiple aspects of learning and memory in young and aged rodents.[2-4,7] For instance, the work of Slutsky et al revealed an 18% increase in short-term memory and a 100% increase in long-term memory with oral administration of Magtein.*
One study examined the effects of Magtein in test mice (genetically altered mice that model age-related cognitive changes).
Li et al found that the test mice not given Magtein exhibited “unequivocal learning deficits,” while the test mice given Magtein performed similarly to normal mice.[3] In short, Magtein helped preserve normal brain function. When magnesium levels in the brain tissue were quantified, the relationship became even
clearer: According to researchers, brain magnesium levels
positively correlated with cognitive function; that is, the lower a
mouse’s brain magnesium level, the poorer its memory function
in the NORT task. Furthermore, histological analysis of brain
tissue showed that Magtein administration preserved synapse
density and NMDA receptor signaling and also had positive
effects on the expression of certain proteins associated with
changes in memory.*[3]
A large-scale human clinical trial has recently been completed.
The results, publication forthcoming, support the in vitro
and animal findings that Magtein positively affects memory,
cognition, and synapse density.*
Magnesium in Stress Management, Sleep Quality, and Mood
Magnesium is known to benefit the body in ways that counter
stress, promote restful sleep, and support a healthy mood.
In rats, magnesium administration attenuated neurologic
changes brought on by chronic mild stress.[8] Additionally, 
by increasing fear memory extinction, Magtein showed promise as a modulator of worry.[4,9] In human studies, magnesium supplementation partially reversed sleep changes associated with aging and improved objective and subjective measures of sleep.[10-12] Improving sleep quality and countering the effects of chronic stress positively impact mood—another area that is beneficially influenced by optimal magnesium status.*[8,9,13,14]

1. Moshfegh AJ, Goldman JD, Ahuja JK, et al. U.S. Department of Agriculture, Agricultural Research Service. What we eat in America, Nhanes 2005-2006. Usual nutrient intakes from
food and water compared to 1997 dietary reference intakes for vitamin D, calcium, phosphorus, and magnesium. http://www.ars.usda.gov/SP2UserFiles/Place/80400530/pdf/0506/
usual_nutrient_intake_vitD_ca_phos_mg_2005-06.pdf. Published July 2009. Accessed November 21, 2014.
2. Slutsky I, Abumaria N, Wu LJ, et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010 Jan 28;65(2):165-77. [PMID: 20152124]
3. Li W, Yu J, Liu Y, et al. Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer’s disease mouse model. Mol Brain. 2014 Sep 13;7(1):65.
[PMID: 25213836]
4. Abumaria N, Yin B, Zhang L, et al. Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic plasticity in the infralimbic prefrontal cortex and lateral
amygdala. J Neurosci. 2011 Oct 19;31(42):14871-81. [PMID: 22016520]
5. Slutsky I, Sadeghpour S, Li B, et al. Enhancement of synaptic plasticity through chronically reduced Ca2+ flux during uncorrelated activity. Neuron. 2004 Dec 2;44(5):835-49. [PMID:
15572114]
6. Wang D, Jacobs SA, Tsien JZ. Targeting the NMDA receptor subunit NR2B for treating or preventing age-related memory decline. Expert Opin Ther Targets. 2014 Oct;18(10):1121-
30. [PMID: 25152202]
7. Mickley GA, Hoxha N, Luchsinger JL, et al. Chronic dietary magnesium-L-threonate speeds extinction and reduces spontaneous recovery of a conditioned taste aversion. Pharmacol
Biochem Behav. 2013 May;106:16-26. [PMID: 23474371]
8. Pochwat B, Szewczyk B, Sowa-Kucma M, et al. Antidepressant-like activity of magnesium in the chronic mild stress model in rats: alterations in the NMDA receptor subunits. Int J
Neuropsychopharmacol. 2014 Mar;17(3):393-405. [PMID: 24067405]
9. Abumaria N, Luo L, Ahn M, et al. Magnesium supplement enhances spatial-context pattern separation and prevents fear overgeneralization. Behav Pharmacol. 2013 Aug;24(4):255-
63. [PMID: 23764903]
10. Held K, Antonijevic IA, Künzel H, et al. Oral Mg(2+) supplementation reverses age-related neuroendocrine and sleep EEG changes in humans. Pharmacopsychiatry. 2002
Jul;35(4):135-43. [PMID: 12163983]
11. Abbasi B, Kimiagar M, Sadeghniiat K, et al. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci.
201 Dec;17(12):1161-69. [PMID: 23853635].
12. Hornyak M, Voderholzer U, Hohagen F, et al. Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study. Sleep. 1998 Aug
1;21(5):501-05. [PMID: 9703590]
13. Fromm L, Heath DL, Vink R, et al. Magnesium attenuates post-traumatic depression/anxiety following diffuse traumatic brain injury in rats. J Am Coll Nutr. 2004 Oct;23(5):529S-
533S. [PMID: 15466958]
13.Eby GA, Eby KL. Rapid recovery from major depression using magnesium treatment. Med Hypotheses. 2006;67(2):362-70. [PMID: 16542786]
Instructions/How to Use:
Dissolve one level scoop in 4 oz water or adjust amount of water to desired sweetness.
First week: one serving per day 
immediately before dinner or one hour before bedtime.
Thereafter: one serving during the day, preferably mid-afternoon, and 
a second serving before bedtime; or use as directed by your healthcare practitioner.
Ingredients:
1 scoop
Magnesium (as Albion® di-magnesium malate, 200 mg
Magtein™ magnesium L-threonate, and TRAACS® magnesium lysinate glycinate chelate)
MagteinTM (magnesium L-threonate) 1 gram
Cautions/Warnings:
Keep tightly closed in a cool, dry place out of reach of children.

Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their 
healthcare practitioner. Do not use if tamper seal is damaged. 

Wheat, gluten, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically 
modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.


 
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