Magnesium-Potassium provides two intracellular cations that are vital to maintaining healthy muscle
contractility, nerve conduction, and blood pressure levels already within the normal range. These minerals
help maintain healthy electrolyte and acid-base balance, and support kidney health and function.*.
Hypokalemia Causes and Concerns Hypokalemia (low blood potassium) can result from excessive sweating, vomiting, and
diarrhea, or the chronic use of any of a wide variety of pharmaceuticals that cause urinary loss of potassium. Some examples
of these include the use of OTCs (eg, aspirin, sodium bicarbonate, laxatives); prescription drugs, such as non-potassiumsparing
diuretics and steroids; and chemotherapeutic drugs, such as cisplatin. Long-term oral supplementation with licorice
extract containing glycyrrhizin can also reduce potassium levels. A host of diseases—including common conditions such as
alcoholism, diabetes, and eating disorders—can also interfere with potassium homeostasis. The diversity and number of
physiological processes dependent upon adequate potassium is significant. Examples such as the need for healthy muscle
contraction, nerve impulse transmission, gastrointestinal and renal function, tissue synthesis, and carbohydrate metabolism
clearly point to the importance of maintaining optimal blood levels of potassium. When potassium levels in the blood are too
low, there is disruption in pH, enzymatic reactions, isotonicity, and the electrodynamic balance of cells. Oral administration
of potassium is an effective means of maintaining healthy blood levels of potassium when risk factors are present, or for
replacing the mineral when it becomes depleted.
Hypomagnesemia Causes and Concerns Hypomagnesemia (low blood magnesium), similar to hypokalemia, is often
seen in alcoholism, severe or prolonged vomiting or diarrhea, as well as in type 2 diabetes where a low magnesium level
is thought to cause renal impairment sooner than expected. Besides the obvious cause of malabsorption, low magnesium
levels may occur due to cirrhosis of the liver, pancreatitis, inflammatory bowel disease, or renal impairment. Low blood
magnesium level is often concurrent with a low potassium level in the blood, hence the combination of these minerals
in Magnesium-Potassium’s formula. Not all forms of magnesium are appropriate for oral replacement. For example, the
solubility, absorption, and bioavailability of magnesium carbonate is limited, and magnesium oxide is likely to cause diarrhea
when used in the dose needed for replacement.
Calcium and the Kidneys The excretion of calcium in the urine through the kidney is a matter of concern, especially in
individuals who are immobilized. A 3-year, prospective, placebo-controlled, double-blind study (n=64) demonstrated that
oral supplementation of potassium-magnesium citrate provided a significant benefit in terms of calcium salt-related kidney
health. Another study demonstrated that the combination of these two minerals increased urinary pH and chelated the
calcium, as well as decreased undissociated uric acid concentration. These and similar studies employed larger doses
of potassium/magnesium citrate than is available in a capsule of Magnesium-Potassium’s formula. Some individuals may
experience bloating, gas, and loose stools when taking supplemental magnesium across a range of doses, though more
so at higher doses. The symptoms are alleviated when the supplement is discontinued; but then its benefit is lost as well.
Citrate The citrate content of this formula is 398 mg (equivalent to 5.24 mEq). It is in the anhydrous form. Although the
amount per capsule in this formula is not considered significant, citrate is considered protective because it forms soluble
complexes with calcium ions and reduces crystallization and aggregation.
1. Ettinger B, Pak CY, Citron JT, et al. Potassium-magnesium citrate is an effective prophylaxis against recurrent calcium oxalate nephrolithiasis. J Urol. 1997 Dec;158(6):2069-73. [PMID: 9366314]
2. Zerwekh JE, Odvina CV, Wuermser LA, et al. Reduction of renal stone risk by potassium-magnesium citrate during 5 weeks of bed rest. J Urol. 2007 Jun;177(6):2179-84. [PMID: 17509313]
3. Caudarella R, Vescini F. Urinary citrate and renal stone disease: the preventive role of alkali citrate treatment. Arch Ital Urol Androl. 2009 Sep;81(3):182-7. [PMID: 19911682]