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DR BILL'S PRODUCTS: NUTRIMEDS
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NATTOKINASE  120 CAPSULES PER BOTTLE $69.95
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Common Uses: Clinical Uses ...

•• Supports Healthy Fibrin Levels*
•• Supports the Smooth Flow of Blood*
•• Supports Healthy Blood Pressure Already Within the Normal
Range*

Nattokinase is an all-natural, potent enzyme that is extracted from natto and highly purified. Natto is a fermented
soybean food that has been consumed in Japan for over 1000 years. Nattokinase has been the subject of many
studies, including human and animal trials. In 1980, researchers discovered that nattokinase demonstrated a positive
effect on blood flow in vitro. Nattokinase may also support cardiovascular health.*

Natto is a fermented, cheese-like food that is popular in Japan where it has been consumed safely for more than 1000 years.
It is made through the fermentation of boiled soybeans by the bacterium Bacillus subtilis natto. In 1980, during a series
of in vitro experiments at the University of Chicago Medical School, Dr. Hiroyuki Sumi discovered that natto could affect
fibrin levels. Fibrin is a whitish, filamentous protein that is formed in blood after a trauma or injury to protect the body from
excessive blood loss. Strands of fibrin can accumulate along the walls of blood vessels and affect blood flow.*
After Dr. Sumi discovered the effect of natto on fibrin, he proceeded to look for natto’s active component. He then isolated
and named this component “nattokinase,” which means “enzyme in natto.” According to Dr. Sumi, a 150 g portion of natto
contains approximately 500 mg of nattokinase.[1] Nattokinase is produced by Bacillus subtilis natto during the soybean
fermentation process. While other soy foods contain enzymes, it is only the natto preparation that contains the nattokinase
enzyme. Nattokinase is not a kinase enzyme, it is a serine proteinase class of enzyme.*
How Nattokinase Works Nattokinase supports healthy levels of fibrin and supports healthy blood flow through protease
enzyme action (e.g., subtilisin protease, bacillopeptidase F).[2,3] Not only does nattokinase act directly on fibrin, but as
demonstrated by in vitro work, its action also causes the release of substances that trigger the body’s production of other
important enzymes that help regulate fibrin formation. Nattokinase can also inhibit a key enzyme that affects extracellular and
arterial vasoconstriction, and it can generate tissue plasminogen activators.[4,5] Other in vitro work revealed that nattokinase
caused a significant, dose-dependent decrease of red blood cell aggregation and low-shear viscosity, and these beneficial
effects were evident at concentrations similar to those achieved with in vivo animal trials.[6] The Japanese have long believed
that natto supports healthy blood flow. Now, as outlined above, modern science has uncovered mechanisms underlying this
belief.*[2-8]
Animal and Human Studies In preliminary research performed by Dr. Sumi and his colleague Masugi Maruyama, extract
of natto (equivalent to 25 mg and 200 mg respectively) showed a healthy influence on blood pressure in Wistar rats and
in humans.[9] In another animal study performed on dogs, nattokinase was tested against a placebo. Oral administration
(1 g nattokinase in four capsules containing 250 mg each) supported normal circulation, as shown by angiogram.[2] More
recently, to examine the effects of nattokinase supplementation on blood pressure in humans, 86 people aged 20 to 80
years participated in an eight-week, randomized, double-blind, placebo-controlled trial. Seventy-three subjects completed
the protocol. The researchers found that oral nattokinase supplementation (2000 FU/capsule) resulted in a healthy effect
on blood flow.[10] NutriMedical’s Nattokinase 50 provides 1000 FU/capsule with a recommended dosage of two capsules
per day.*
It is important to note that both natto and nattokinase have been demonstrated to have activity in humans, whereas
supplementing with boiled soybeans did not.[2] Animal research has demonstrated that nattokinase escapes the action of
digestive enzymes and is absorbed from the small intestine to perform in plasma.*[11,12]


References
1. Sumi H, Hamada H, Tsushima H, et al. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet. Experientia. 1987 Oct 15;43(10):1110-11. [PMID: 3478223]
2. Sumi H, Hamada H, Nakanishi K, et al. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol. 1990;84(3):139-43. [PMID: 2123064]
3. Purified filtrate of Bacillus subtilis natto culture. JAFRA. http://www.jafra.gr.jp/eng/natto1.html. Accessed August 16, 2012.
4. Murakami K, Yamanaka N, Ohnishi K, et al. Inhibition of angiotensin I converting enzyme by subtilisin NAT (nattokinase) in natto, a Japanese traditional fermented food. Food Funct. 2012 Mar 27. [Epub ahead of print] [PMID: 22453301]
5. Yatagai C, Maruyama M, Kawahara T, et al. Nattokinase-promoted tissue plasminogen activator release from human cells. Pathophysiol Haemost Thromb. 2008;36(5):227-32. [PMID: 19996631]
6. Pais E, Alexy T, Holsworth RE Jr, et al. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc. 2006;35(1-2):139-42. [PMID: 16899918]
7. Fujita M, Hong K, Ito Y, et al. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995 Oct;18(10):1387-91. [PMID: 8593442]
8. Suzuki Y, Kondo K, Ichise H, et al. Dietary supplementation with fermented soybeans suppresses intimal thickening. Nutrition. 2003 Mar;19(3):261-64. [PMID: 12620531]
9. Maruyama M, Sumi H. Effect of natto diet on blood pressure. JAFRA. http://www.jafra.gr.jp/eng/natto7.html. Accessed August 14, 2012.
10. Kim JY, Gum SN, Paik JK, et al. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens Res. 2008 Aug;31(8):1583-88. [PMID: 18971533]
11. Fujita M, Ohnishi K, Takaoka S, et al. Antihypertensive effects of continuous oral administration of nattokinase and its fragments in spontaneously hypertensive rats. Biol Pharm Bull. 2011;34(11):1696-701. [PMID: 22040882]
12. Fujita M, Hong K, Ito Y, et al. Transport of nattokinase across the rat intestinal tract. Biol Pharm Bull. 1995 Sep;18(9):1194-96. [PMID: 8845803]
Instructions/How to Use: Take one to two capsules twice daily at least 30 minutes before or two hours after a meal, or as directed by your healthcare practitioner.
Ingredients: Nattokinase (20,000 FU/g†)(NSK-SD®)

Serving Size: 2 Capsules

Servings Per Container: 60**

Daily Value not established.Supplement FactsAmount Per Serving%Daily Value100 mg**
Cautions/Warnings: DOES NOT CONTAIN ...

Wheat, gluten, corn protein, yeast, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, or preservatives.


*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


 
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