NutriMedical   Register     Sign-In     View Cart 
  Dr. Bill Deagle, M.D.NewsPRODUCTSWellness ConditionsContact UsHome   Phone Orders 888-212-8871  
Products & News Search:  

  Products / Product Details

< Back to Product Listing

DR BILL'S PRODUCTS: NUTRIMEDS
name how sold price
MELATONIN TR 90 tablets per bottle $24.95
$23.20
Download Product Sheet
Common Uses: SLEEP INDUCTION AND MAINTENANCE

•• Support Synchronization of the Body’s Daily Biorhythms*
•• Support Restful Sleep*
•• Direct and Indirect Antioxidant Support*
•• Support Healthy Immune Response*
•• Support Brain Health*

Melatonin TR is a vegetarian formula with a biphasic delivery system that releases melatonin quickly and
then steadily. Melatonin is naturally produced in the pineal gland in response to changes in light exposure;
it helps promote healthy sleep patterns as well as antioxidant and immune activities. Melatonin TR can
support these functions by helping to maintain normal levels of melatonin in the body.*

Melatonin is a neurohormone produced from tryptophan by the pineal gland when it is stimulated by darkness. While
melatonin regulates many other hormones; its primary function appears to be regulation of the body’s daily and annual
biological rhythms.*
Oral supplementation has been shown to have some benefit with regard to time to sleep onset, total sleep time, and sleep
efficiency.[1] Noteworthy advantages over pharmaceutical sleep aids are improved performance upon wakening and the
absence of memory impairment.[2,3] According to studies, daytime melatonin supplementation by travelers crossing time
zones and/or shift workers also promotes sleep.*[4]
Research has shown that melatonin not only fights free radicals during sleep, but also stimulates the body’s own antioxidant
systems. For example, it reduced harmful oxidized cholesterol (LDL) in post-menopausal women.[5] Melatonin’s antioxidant
capacity also accounts for its role as a neuroprotectant. By delivering antioxidant benefits and correcting the circadian
rhythm, melatonin could support cognitive function.*[6,7]
A decrease in plasma melatonin correlates with a decline in immune function in some individuals beginning around the age
of sixty. Interestingly, lymphoid cells are an important physiological source of melatonin in humans.The hormone appears
to stimulate production of T helper (TH) cells and their release of interleukin-2, gamma interferon and opiod peptides.[8]
Considering the decline in melatonin synthesis with age, exogenous supplementation with the hormone has long been of
interest in anti-aging protocols.*[9,10]
The addition of pyridoxine in this formula supports the biosynthesis of melatonin and may also enhance dream recall.*
The biphasic delivery system consists of 1mg of melatonin in the coating solution and the remainder in the tablet core. The
melatonin in the coating solution is immediately released upon digestion. The melatonin in the tablet core is released over
a 6-hour period. The tablet core contains a tableting agent, hydroxypropyl methylcellulose that works by forming a gel layer
when hydrated. This gel layer acts as a diffusion barrier to control the rate of release of the melatonin in the tablet core.
As the tablet travels through the intestine, the gel layer slowly erodes to release the melatonin, which then is available for
absorption in the intestine.*
All NutriMedical Formulas Meet or Exceed cGMP Quality Standards
•• Support Synchronization of the Body’s Daily Biorhythms*
•• Support Restful Sleep*
•• Direct and Indirect Antioxidant Support*
•• Support Healthy Immune Response*
•• Support Brain Health*
Clinical Applications
Melatonin TR is a vegetarian formula with a biphasic delivery system that releases melatonin quickly and
then steadily. Melatonin is naturally produced in the pineal gland in response to changes in light exposure;
it helps promote healthy sleep patterns as well as antioxidant and immune activities. Melatonin TR can
support these functions by helping to maintain normal levels of melatonin in the body.*

References
1. Brzezinski A, Vangel MG, Wurtman RJ, et al. Effects of exogenous melatonin on sleep: a meta-analysis. Sleep Med Rev.2005;9:41-50. [PMID: 15649737]
2. Paul MA, et al.Melatonin and zopiclone as pharmacologic aids to facilitate crew rest. Aviat Space Environ Med. 2001 Nov;72(11):974-84. [PMID: 11718517]
3. Wesensten NJ, Balkin TJ, Reichardt RM et al. Daytime sleep and performance following a zolpidem and melatonin cocktail. Sleep. 2005;28:93-103. [PMID: 15700725]
4. Srinivasan V, et al. Jet lag: therapeutic use of melatonin and possible application of melatonin analogs. Travel Med Infect Dis. 2008 Jan-Mar;6(1-2):17-28.[PMID: 18342269]
5. Wakatsuki A, et al. Melatonin inhibits oxidative modification of low-density lipoprotein particles in normolipidemic post-menopausal women. J Pineal Res. 2000;28:136-142 [PMID: 10739299]
6. Peck JS, et al. Cognitive effects of exogenous melatonin administration in elderly persons: a pilot study. Am J Geriatr Psychiatry. 2004;12:432-436. [PMID: 15249281]
7. Asayama K, Yamadera H, Ito T, et al. Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and noncognitive functions in Alzheimer type dementia. J Nippon Med Sch. 2003;70:334-341. [PMID: 12928714]
8. Cardinali DP, et.al. Melatonin and the immune system in aging. Neuroimmunomodulation. 2008;15(4-6):272-8. [PMID: 19047804]
9. Armstrong SM, Redman JR. Melatonin: A chronobiotic with anti-aging properties? Med Hypotheses 1991;34: 300-9 [PMID: 1865836]
10. Rozencwaig R, Grad BR, Ochoa J. The role of melatonin and serotonin in aging. Med Hypotheses 1987;23: 337-52 [PMID: 2889131]
11. Miyamoto A, et.al. Serum melatonin kinetics and long-term melatonin treatment for sleep disorders in Rett syndrome. Brain Dev. 1999 Jan;21(1):59-62 [PMID: 10082254]
12. Arendt J. Safety of melatonin in long-term use. J Biol Rhythms 1997;12:673-681 [PMID: 9406044]
13. Voordouw BC, et.al. Melatonin and melatonin-progestin combinations alter pituitary-ovarian function in women and can inhibit ovulation. J Clin Endocrinol Metab. 1992 Jan;74(1):108-17. [PMID: 1727807]
14. Abd-Allah AR, et al. Effect of melatonin on estrogen and progesterone receptors in relation to uterine contraction in rats. Pharmacol Res. 2003 Apr;47(4):349-54 [PMID: 12644393]
*
Instructions/How to Use: Take one tablet one hour before sleep time for induction and maintenance of sleep. 
Ingredients: B6 Pyridoxine HCl 10 mg 
Melatonin 1 mg immediate and 4 mg timed release


Does NOT Contain >>

Wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, or preservatives.
Cautions/Warnings: Cautions >>

If you are under medical supervision or using any tranquilizers or sedatives, seek the advice of your healthcare practitioner prior to using. Consult your healthcare practitioner before using if you have an autoimmune condition or depressive disorder or are a pregnant or lactating woman. Not for use by children under 12 years of age. Do not take when operating machinery or driving a vehicle.


 
Product Specials


   VITAMINERALMAX  SALE + FREE SHIPPING!
120 caps
$34.95
$32.50



 QRMA DEVICE + FREE Consults* & Wellness Analysis + FREE Shipping
QRMA Wellness Analysis + NutriMeds Consult
$1,599.95
$1,199.96



ALLERGONE 15%OFF + FREE SHIPPING!
60 caps bottle
$89.95
$62.96



KARDIOVASC CAPS  FREE SHIPPING
180 caps 2 + months
$69.95
$65.05



Additional Links

RADCast Radiation Articles and Daily Reports

ORAL SYSTEM BIOLOGY DR FARRAND ROBSON DDS TMJ OBSTRUCTIVE SLEEP APNEA

International Advocates for Health Freedom -- THE REAL FIGHTERS AGAINST WEAPONIZATION OF FOOD AND ELIMINATION OF NUTRACEUTICAL WELLNESS ACCESS

NO CODEX GENOCIDE! DEFEND DSHEA BY DEFENDING AMERICA FROM ITS PLANNED DESTRUCTION- DEFEND HEALTH FREEDOM GLOBALLY BY OPPOSING GLOBALIZATION

Mobile Phone Radiation: Is it safe or not? Part 1:15 YouTuvbe Video

Association of Prolife Physicians

Shocking True Story US MARINE IN RENAL FAILURE AFTER SECRET VACCINE - GUINEA PIGS WITHOUT CONSENT

Blueprint for influenza pandemic

"We Become Silent - The Last Days Of Health Freedom The Codex-CAFTA Documentary" (2006) A 28-minute video by Kevin Miller

2003-2017 NutriMedical, Inc. All Rights Reserved.   Terms of Use   |   Privacy Policy   |   Site Map