Normal stomach acidity is needed to operate digestive enzymes, eliminate pathogens in food, and alkalinize the body with bicarbonate as a byproduct of stomach acidification.
This formula has several very efficacious formulas to stimulate gastric HCl and also promote return of natural stomach metabolism to produce normal acidity and alkalinization of the body as a byproduct.
Supports Healthy Gastric pH • Supports Healthy Digestion; Especially of Dietary Protein • Supports Proper Gastric Emptying, Reducing Risk of Reflux • Supports Absorption of Certain Macro- & Micro- Nutrients • Supports Healthy Balance of Flora in the G.I. Tract
DigestEase provides optimal nutritional support for the digestive system by featuring the acidifying factors Glutamic Acid and Betaine HCl. Additionally, DigestEase provides the proteolytic enzyme, pepsin; along with the herbal bitter, gentian root, which has been traditionally used to support healthy digestion. Glutamic acid and Betaine HCl are necessary for adequate absorption of protein, calcium, vitamin B12, iron and more.
DigestEase is formulated to restore adequate gastric acidity. Secretion of gastric acid may be reduced by the natural aging process (beginning around the age of 35), drugs or disease.[1,2] Inadequate secretion contributes to a wide range of symptoms, nutritional deficiencies and a variety of chronic disorders.[3,4,5] Orally-ingested pathogens are likely to survive if gastric acidity is sub-optimal, causing bacterial or fungal overgrowth in the GI tract. Glutamic Acid, also called glutamate is an amino acid a well-functioning body can obtain either from dietary protein or can synthesize endogenously from ornithine and arginine. It is not the same as glutamine. Glutamic acid is used in DigestEase as an acidifying agent. Betaine Hydrochloride, the acidic form of betaine, a natural, vitamin-like substance found in beets, grains and other foods is manufactured and has traditionally been used for more than 100 years as a digestive aid, to enhance absorption of some minerals and other nutrients, and in nutritional protocols for many disorders. It is the same as physiologic stomach acid. Pepsin, one of the first enzymes to initiate proteolysis, is synthesized in the parietal cells of the gastric mucosa and secreted as the inactive zymogen precursor, pepsinogen. Hydrochloric acid activates pepsinogen to convert to pepsin once it is outside of the cell. This activation sets up a chain reaction leading to the production of still more pepsin. Porcine pepsin has been included in DigestEase in addition to the Betaine HCl with the goal of promoting more endogenous pepsin production. Gentian Root, (Gentiana lutea), used for centuries to treat moderate digestive disorders, contains two of the most bitter substances known, gentiopicrin and amarogentin. The bitter taste can be detected even at 50,000 times dilution. These glycosides act on taste bud receptors to stimulate the secretion of saliva in the mouth and hydrochloric acid in the stomach. In fact, the effectiveness of Gentian Root in stimulating the endogenous production of HCl may allow a person to discontinue DigestEase after a period of use.
1. Lovat LB. Age related changes in gut physiology and nutritional status. Gut. 1996 Mar;38(3):306-9 [PMID: 8675079] 2. Vilkin A, et al. Higher gastric mucin secretion and lower gastric acid output in first-degree relatives of gastric cancer patients. J Clin Gastroenterol. 2008 Jan;42(1):36-41 [PMID: 18097287] 3. Moorchung N, et al. Cytokine gene polymorphisms and the pathology of chronic gastritis. Singapore Med J. 2007 May;48(5):447-54 [PMID: 17453104] 4. Bredenoord AJ, Baron A, Smout AJ. Symptomatic gastro-oesophageal reflux in a patient with achlorhydria. Gut. 2006 Jul;55(7):1054-5 [PMID: 16766765] 5. Juncà J, et al. Detection of early abnormalities in gastric function in first-degree relatives of patients with pernicious anemia. Eur J Haematol. 2006 Dec;77(6):518-22. [PMID: 17042761] 6. Tennant SM, et al. Influence of gastric acid on susceptibility to infection with ingested bacterial pathogens. Infect Immun. 2008 Feb;76(2):639- 45. Epub 2007 Nov19 [PMID: 18025100] 7. English J. Heartburn and gastritis not always caused by too much acid. http://www.vrp.com/articles/735.asp [Accessed 06 July 04]